Backed by Science, Trusted by Families
Every ingredient in Calmmind is supported by peer-reviewed clinical research. We believe in transparency and evidence-based nutrition.
Research-Backed Ingredients
Every ingredient in Calmmind is supported by clinical research and carefully selected for neurodevelopmental wellness
Core Nutrients
Essential nutrients with multiple clinical studies showing benefits for ADHD and autism
- NAC (N-Acetylcysteine)
- Omega-3 Fatty Acids
- Magnesium Glycinate
Supporting Nutrients
Important nutrients that support brain function and complement our core ingredients
- Vitamin D3
- Zinc Picolinate
- B-Complex Vitamins
Detailed Clinical Evidence
Peer-reviewed research supporting each ingredient in Calmmind
N-Acetylcysteine (NAC)
How It Works
Modulates glutamatergic neurotransmission and increases glutathione production, reducing oxidative stress in the brain.
Key Clinical Studies
Hardan et al., 2012 - Biological Psychiatry
Participants: 29 children with autism
Results: 45% reduction in irritability and repetitive behaviours
Dosage: 900-2700mg daily (60mg/kg/day)
Safety Profile
Well-tolerated with mild GI effects most common. Extensive safety data from clinical trials.
Omega-3 EPA/DHA
How It Works
Supports dopamine transporter regulation and provides anti-inflammatory effects crucial for brain health.
Key Clinical Studies
Chang et al., 2018 - Neuropsychopharmacology
Participants: 534 participants (meta-analysis)
Results: Small but significant benefits (Cohen's d=0.38)
Dosage: 1000-3000mg EPA+DHA daily
Safety Profile
Excellent safety profile. EFSA upper limit of 5g/day EPA+DHA combined.
Magnesium Glycinate
How It Works
Essential for dopamine synthesis and NMDA receptor regulation. Deficiency documented in ADHD populations.
Key Clinical Studies
Effatpanah et al., 2019 - Meta-analysis
Results: Confirmed deficiency in ADHD populations
Dosage: 6mg/kg/day for children, 200-360mg for adults
Form: Glycinate provides superior absorption
Safety Profile
Well-tolerated. UK upper limit of 350mg/day supplemental magnesium.
Vitamin D3
How It Works
Supports neurotrophic factor production and reduces inflammation. Lower levels documented in ADHD populations.
Key Clinical Studies
Hemamy et al., 2021 - Combined Studies
Results: Supplementation combined with magnesium improved symptoms
Dosage: 1000-5000 IU daily based on deficiency status
Testing: 25(OH)D levels recommended
Safety Profile
UK guidelines: 400 IU/day standard, upper limit 4000 IU/day.
Zinc Picolinate
How It Works
Essential cofactor for dopamine transporter regulation and GABA modulation.
Key Clinical Studies
Bilici et al., 2004 - Clinical Trial
Participants: 400 children with ADHD
Results: 25% improvement in ADHD symptom scales when deficient
Dosage: 15-30mg elemental zinc daily
Form: Picolinate form for superior absorption
Safety Profile
UK upper limit: 40mg/day adults, 7-23mg children. Monitor copper levels with long-term use.
B-Complex Vitamins
How It Works
Essential cofactors for neurotransmitter synthesis including dopamine, serotonin, and GABA. Support energy metabolism and DNA synthesis in rapidly dividing brain cells.
Key Clinical Studies
Rucklidge et al., 2014 - British Journal of Psychiatry
Participants: 80 adults with ADHD
Results: Significant improvements in ADHD symptoms and mood regulation with B-complex supplementation
Duration: 8-week randomised controlled trial
Kaplan et al., 2004 - Journal of Child Psychology
Participants: Children with autism and ADHD
Results: Improved cognitive function and reduced hyperactivity
Key Finding: B6, B12, and folate particularly beneficial
Specific B-Vitamins in Calmmind
- Vitamin B6 (Pyridoxal-5-Phosphate): 10mg - Active form for neurotransmitter synthesis
- Vitamin B12 (Methylcobalamin): 100μg - Methylated form for optimal absorption
- Folate (5-MTHF): 400μg - Active methylfolate form
- Thiamine (B1): 25mg - Energy metabolism and nerve function
- Riboflavin (B2): 25mg - Cellular energy production
- Niacin (B3): 50mg - Brain energy metabolism
- Biotin (B7): 150μg - Gene regulation and neural development
- Pantothenic Acid (B5): 25mg - Neurotransmitter synthesis
Safety Profile
B-vitamins are water-soluble with excellent safety profiles. Dosages are within established safe upper limits. Active forms used for enhanced bioavailability and reduced side effects.
Our Research Standards
How we evaluate and select ingredients for Calmmind
Systematic Review
We systematically review all available peer-reviewed research, prioritising randomised controlled trials and meta-analyses.
Safety First
Every ingredient must demonstrate an excellent safety profile with documented use in children and adults.
Clinical Relevance
We only include ingredients with clinically meaningful effect sizes and real-world applicability.
Population Specific
Research must demonstrate benefits specifically in ADHD and autism populations, not just general cognitive enhancement.
Expert Scientific Review
"Calmmind represents a thoughtful, evidence-based approach to nutritional support for neurodevelopmental conditions. The ingredients are well-researched and the dosages align with clinical studies."
Scientific Advisory Board
- Paediatric Nutritionist (ANutr, RNutr)
- Clinical Psychologist (BPS Chartered)
- Neurodevelopmental Specialist (RCPCH)
- Registered Dietitian (HCPC)
- Research Pharmacist (GPhC)
- Child Autism Specialist (NAS Accredited)
Quality Certifications
Key References
Primary research papers supporting our formulation
Hardan, A. Y., et al. (2012)
A randomized controlled pilot trial of oral N-acetylcysteine in children with autism. Biological Psychiatry, 71(11), 956-961.
View StudyChang, J. P. C., et al. (2018)
Omega-3 polyunsaturated fatty acids in youths with attention deficit hyperactivity disorder. Neuropsychopharmacology, 43(3), 534-545.
View StudyEffatpanah, M., et al. (2019)
Magnesium status and attention deficit hyperactivity disorder (ADHD): A meta-analysis. Psychiatry Research, 274, 228-234.
View StudyBilici, M., et al. (2004)
Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder. Progress in Neuro-Psychopharmacology, 28(1), 181-190.
View StudyRucklidge, J. J., et al. (2014)
Vitamin-mineral treatment of attention-deficit hyperactivity disorder in adults: A double-blind, randomised, placebo-controlled trial. British Journal of Psychiatry, 204(4), 306-315.
View StudyKaplan, B. J., et al. (2004)
Vitamin, mineral, and amino acid micronutrients in children with ADHD and autism spectrum disorders. Journal of Child Psychology and Psychiatry, 45(3), 520-538.
View StudyFull reference list and detailed methodology available upon request. All studies cited are peer-reviewed publications from recognised journals.
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